Eomestm2.1(flpo/ERT2)Zjh
Targeted Allele Detail
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Symbol: |
Eomestm2.1(flpo/ERT2)Zjh |
Name: |
eomesodermin; targeted mutation 2.1, Z Josh Huang |
MGI ID: |
MGI:6720888 |
Synonyms: |
Tbr2-FlpER |
Gene: |
Eomes Location: Chr9:118307259-118315176 bp, + strand Genetic Position: Chr9, 70.21 cM, cytoband F3
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Alliance: |
Eomestm2.1(flpo/ERT2)Zjh page
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Eomestm2.1(flpo/ERT2)Zjh expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: The allele was generated by inserting a 2A-flpoER expression cassette in-frame before the STOP codon of the Eomes gene. The targeting vectors generated using BAC clones from the RPCI-23&24 library were electroporated into a 129SVj/B6 hybrid ES cell line (v6.5). The Resulting ES cell clones were used for tetraploid complementation to obtain male heterozygous mice. The neo selection cassette was excised by crossing to cre expressing mice.
(J:323692)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Eomes
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Eomes Mutation: |
41 strains or lines available
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Original: |
J:323692 Matho KS, et al., Genetic dissection of the glutamatergic neuron system in cerebral cortex. Nature. 2021 Oct;598(7879):182-187 |
All: |
1 reference(s) |
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