Dnah11^tm1Hmd
Targeted Allele Detail

Summary

• Symbol: Dnah11^tm1Hmd
• Name: dynein, axonemal, heavy chain 11; targeted mutation 1, Hiroshi Hamada
• MGI ID: MGI:6720868
• Synonyms: Dnah11^Venus
• Gene: Dnah11 Location: Chr12:117841717-118162778 bp, - strand Genetic Position: Chr12, 63.25 cM
• Alliance: Dnah11^tm1Hmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301033
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Intragenic deletion
• Mutation details: The Venus fluorescent protein gene, preceded and followed by sequence for (Gly₄Ser)₃ linker peptide, was inserted in-frame into exon 43 to create a Dnah11-Venus fusion protein gene. A loxP site flanked neomycin resistance gene cassette was inserted into intron 43. (J:301033)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dnah11 Mutation: 222 strains or lines available

References

• Original: J:301033 Ide T, et al., CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components. PLoS Genet. 2020 Dec;16(12):e1009232
• All: 1 reference(s)