Card19^em1Ieb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Card19^em1Ieb
• Name: caspase recruitment domain family, member 19; endonuclease-mediated mutation 1, Igor E Brodsky
• MGI ID: MGI:6720371
• Synonyms: Card19^deltaCARD
• Gene: Card19 Location: Chr13:49356426-49369471 bp, - strand Genetic Position: Chr13, 25.15 cM
• Alliance: Card19^em1Ieb page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 genome editing is used to delete exons 2-3. The deletion removes amino acids XX including the entire CARD and giving a predicted protein product of 87 amino acids. (J:313687)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Card19 Mutation: 11 strains or lines available

References

• Original: J:313687 Bjanes E, et al., Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection. PLoS Pathog. 2021 Oct;17(10):e1009967
• All: 1 reference(s)