Ttc21a^em1Pvt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ttc21a^em1Pvt
• Name: tetratricopeptide repeat domain 21A; endonuclease-mediated mutation 1, Pamela V Tran
• MGI ID: MGI:6719385
• Synonyms: Thm2^-, Thm2^delta4-8
• Gene: Ttc21a Location: Chr9:119766672-119796859 bp, + strand Genetic Position: Chr9, 71.33 cM, cytoband F4
• Alliance: Ttc21a^em1Pvt page

Mutation origin

• Strain of Origin: (FVB/N x C57BL/6J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology deleted exons 4-8 and caused a premature stop codon. (J:307178)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ttc21a Mutation: 68 strains or lines available

References

• Original: J:307178 Wang W, et al., Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis. FASEB J. 2020 May;34(5):6369-6381
• All: 1 reference(s)