Tg(Ins2-Eif2s1)3Rjk
Transgene Detail

Summary

• Symbol: Tg(Ins2-Eif2s1)3Rjk
• Name: transgene insertion 3, Randal J Kaufman
• MGI ID: MGI:6719213
• Synonyms: eIF2alpha beta-Tg
• Transgene: Tg(Ins2-Eif2s1)3Rjk Location: unknown
• Alliance: Tg(Ins2-Eif2s1)3Rjk page

Transgene origin

• Strain of Origin: C57BL/6J x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-Eif2s1)3Rjk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Eif2s1 (MGI:95299)

• Tg(Ins2-Eif2s1)3Rjk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: This transgene construct contains the following elements: the rat insulin 2 promoter, the mouse eukaryotic translation initiation factor 2 subunit 1 alpha cDNA, and mouse H2-Ea poly(A) signal sequences. The Ins2 promoter drives Eif2s1 expression specifically in pancreatic beta cells. Founder 3 has an estimated four copies of the transgene. (J:151620)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:151620 Back SH, et al., Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab. 2009 Jul;10(1):13-26
• All: 1 reference(s)