Pomctm1.1(cre)Lowl
Targeted Allele Detail
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Symbol: |
Pomctm1.1(cre)Lowl |
Name: |
pro-opiomelanocortin-alpha; targeted mutation 1.1, Bradford B Lowell |
MGI ID: |
MGI:6718623 |
Synonyms: |
Pomc-IRES-Cre |
Gene: |
Pomc Location: Chr12:4004951-4010642 bp, + strand Genetic Position: Chr12, 1.99 cM
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Alliance: |
Pomctm1.1(cre)Lowl page
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Germline Transmission: |
Earliest citation of germline transmission:
J:303221
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (No functional change, Recombinase) |
Mutation: |
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Insertion
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Pomctm1.1(cre)Lowl expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Pomc (MGI:97742) |
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Mutation details: A selection cassette containing an internal ribosomal entry sequence (IRES) linked to Cre-recombinase and an Frt-flanked kanamycin resistance gene was targeted just downstream of the stop codon of the Pomc gene, so that Cre-recombinase expression was driven by the endogenous gene. Flpe recombinase transgene mice were then used to remove the kanamycin selection cassette.
(J:303221)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Pomc
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pomc Mutation: |
19 strains or lines available
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Original: |
J:303221 Fenselau H, et al., A rapidly acting glutamatergic ARC-->PVH satiety circuit postsynaptically regulated by alpha-MSH. Nat Neurosci. 2017 Jan;20(1):42-51 |
All: |
1 reference(s) |
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