Vcp^tm1.1Yph
Targeted Allele Detail

Summary

• Symbol: Vcp^tm1.1Yph
• Name: valosin containing protein; targeted mutation 1.1, Yi-Ping Hsueh
• MGI ID: MGI:6718524
• Synonyms: VCP R95G
• Gene: Vcp Location: Chr4:42979964-43000507 bp, - strand Genetic Position: Chr4, 22.95 cM
• Alliance: Vcp^tm1.1Yph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236751
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: A C to G mutation resulting in an arginine to glycine substitution at amino acid 95 (R95G) was introduced in exon 3. In addition, a loxP-flanked neomycin cassette was inserted in the third intron. Cre-mediated recombination removed the neomycin cassette. (J:236751)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vcp Mutation: 52 strains or lines available

References

• Original: J:236751 Shih YT, et al., VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation. Nat Commun. 2016 Mar 17;7:11020
• All: 2 reference(s)