Trpm4^{tm1.1(cre)Zuf}
Targeted Allele Detail

Summary

• Symbol: Trpm4^{tm1.1(cre)Zuf}
• Name: transient receptor potential cation channel, subfamily M, member 4; targeted mutation 1.1, Frank Zufall
• MGI ID: MGI:6718321
• Synonyms: Trpm4-IRES-Cre
• Gene: Trpm4 Location: Chr7:44952579-44983495 bp, - strand Genetic Position: Chr7, 29.24 cM
• Alliance: Trpm4^{tm1.1(cre)Zuf} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:304490
• Parent Cell Line: BAC-BA1 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S/SvEv)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Trpm4^{tm1.1(cre)Zuf} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Trpm4 (MGI:1915917)

• Mutation details: An IRES-Cre-Frt-Neo-Frt was inserted after the STOP codon of the Trpm4 gene using homologous recombination. The neo cassette was removed by crossing with Flp-recombinase expressing mice. (J:304490)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Trpm4 (mouse) Summary of all recombinase alleles driven by Trpm4. Comparative matrix view of recombinase activities Alliance mouse Trpm4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpm4 Mutation: 58 strains or lines available

References

• Original: J:304490 Eckstein E, et al., Cyclic regulation of Trpm4 expression in female vomeronasal neurons driven by ovarian sex hormones. Mol Cell Neurosci. 2020 Jun;105:103495
• All: 1 reference(s)