Actrt3^em1Hsc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Actrt3^em1Hsc
• Name: actin related protein T3; endonuclease-mediated mutation 1, Hubert Schorle
• MGI ID: MGI:6718284
• Gene: Actrt3 Location: Chr3:30651221-30654021 bp, - strand Genetic Position: Chr3, 14.27 cM, cytoband A3
• Alliance: Actrt3^em1Hsc page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted 314 bp that result in the loss of parts of exon 1 and 2 creating null alleles due to premature stop codons. (J:379495)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Actrt3 Mutation: 29 strains or lines available

References

• Original: J:379495 Kovacevic A, et al., Actin-related protein T3 is required for acrosome biogenesis and sperm function in mice. Development. 2026 Feb 1;153(3):dev205283
• All: 1 reference(s)