Ogdh^tm1.1Mipo
Targeted Allele Detail

Summary

• Symbol: Ogdh^tm1.1Mipo
• Name: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide); targeted mutation 1.1, Michael Potente
• MGI ID: MGI:6718277
• Synonyms: Ogdh^fl
• Gene: Ogdh Location: Chr11:6241633-6306642 bp, + strand Genetic Position: Chr11, 3.94 cM, cytoband A1
• Alliance: Ogdh^tm1.1Mipo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306790
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The allele was generated by flanking exons 3 and 4 with loxP sites. A self-deleting neomycin cassette was removed in ES cells. (J:306790)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ogdh Mutation: 77 strains or lines available

References

• Original: J:306790 Andrade J, et al., Control of endothelial quiescence by FOXO-regulated metabolites. Nat Cell Biol. 2021 Apr;23(4):413-423
• All: 2 reference(s)