Gt(ROSA)26Sor^{tm2(CAG-Hbegf,-EGFP)Bcgen}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(CAG-Hbegf,-EGFP)Bcgen}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Biocytogen LLC
• MGI ID: MGI:6715677
• Synonyms: Gt(ROSA)26Sortm2(CAG-LSL-DTR-EGFP)
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(CAG-Hbegf,-EGFP)Bcgen} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306087
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(CAG-Hbegf,-EGFP)Bcgen} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Hbegf

• Mutation details: The following elements were inserted into the locus: the CAG promoter, a loxP site flanked STOP cassette, Diphtheria toxin receptor cDNA, sequence for 2A self-cleaving peptide, and the green fluorescent protein reporter gene. Only after cre-mediated deletion of the STOP cassette will this allele express the DTR and EGFP genes. (J:306087)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:306087 Mu W, et al., Hypothalamic Rax(+) tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice. Nat Commun. 2021 Apr 16;12(1):2288
• All: 2 reference(s)