Igf2r^tm2760.1Arte
Targeted Allele Detail

Summary

• Symbol: Igf2r^tm2760.1Arte
• Name: insulin-like growth factor 2 receptor; targeted mutation 2760.1, TaconicArtemis
• MGI ID: MGI:6715486
• Synonyms: Igf2r^I1565A, Igf2r^{tm2760(I1565A)Arte}
• Gene: Igf2r Location: Chr17:12901293-12988551 bp, - strand Genetic Position: Chr17, 8.64 cM, cytoband A-C
• Alliance: Igf2r^tm2760.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297302
• Parent Cell Line: ART B6 3.6 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting vector introduced an FRT flanked puromycin selection cassette into intro 31 and mutated exon 34 (ATC to GCC) resulting in the amino acid substitution ot isoleucine with alanine at position 1565 (I1565A). (J:297302)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Igf2r Mutation: 103 strains or lines available

References

• Original: J:297302 Hughes J, et al., Maternal transmission of an Igf2r domain 11: IGF2 binding mutant allele (Igf2r(I1565A)) results in partial lethality, overgrowth and intestinal adenoma progression. Sci Rep. 2019 Aug 6;9(1):11388
• All: 1 reference(s)