Tg(ACTA1-DMD*)33Dua
Transgene Detail

Summary

• Symbol: Tg(ACTA1-DMD*)33Dua
• Name: transgene insertion 33, Dongsheng Duan
• MGI ID: MGI:6715108
• Synonyms: DH2-R15
• Transgene: Tg(ACTA1-DMD*)33Dua Location: unknown
• Alliance: Tg(ACTA1-DMD*)33Dua page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTA1-DMD*)33Dua expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DMD (1756)

  Dmd	(MGI:94909)

• Mutation details: The transgenic construct contains a full length human dystrophin gene modified by the deletion of the H2 domain and deletion of spectrin-like repeat 4 through repeat 19 and the C-terminus to generate a micro-dystrophin cDNA (DH2-R19) under the control of the human skeletal alpha 1 actin (ACTA1) promoter. (J:146281)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:146281 Lai Y, et al., Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy. J Clin Invest. 2009 Mar;119(3):624-35
• All: 2 reference(s)