Ccr7^tm1.1Iaai
Targeted Allele Detail

Summary

• Symbol: Ccr7^tm1.1Iaai
• Name: C-C motif chemokine receptor 7; targeted mutation 1.1, Iannis Aifantis
• MGI ID: MGI:6714303
• Synonyms: Ccr7^fl
• Gene: Ccr7 Location: Chr11:99035025-99045903 bp, - strand Genetic Position: Chr11, 62.92 cM, cytoband D
• Alliance: Ccr7^tm1.1Iaai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305949
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting construct is designed to contain from 5' to 3'; an FRT site, a loxP site, a PGK-neomycin resistance cassette, an FRT site, a loxP site, inserted into intron 2. A third loxP site is inserted in intron 3. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 3 floxed. (J:305949)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccr7 Mutation: 29 strains or lines available

References

• Original: J:305949 Koscso B, et al., Gut-resident CX3CR1(hi) macrophages induce tertiary lymphoid structures and IgA response in situ. Sci Immunol. 2020 Apr 10;5(46)
• All: 1 reference(s)