Ldb3^tm1.1Amank
Targeted Allele Detail

Summary

• Symbol: Ldb3^tm1.1Amank
• Name: LIM domain binding 3; targeted mutation 1.1, Ami Mankodi
• MGI ID: MGI:6712785
• Synonyms: Ldb3^Ala165Val
• Gene: Ldb3 Location: Chr14:34248560-34310639 bp, - strand Genetic Position: Chr14, 20.83 cM, cytoband B
• Alliance: Ldb3^tm1.1Amank page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305082
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: The targeting vector is designed to insert an amino acid substitution at position 165 altering alanine to valine (A165V; chr14:34571772 C to T; GRCm38/mm10) into exon 6. The substitution is followed by a loxP-flanked neomycin cassette in intron 6. Cre-mediated recombination removed the loxP-flanked neo cassette. (J:305082)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ldb3 Mutation: 44 strains or lines available

References

• Original: J:305082 Pathak P, et al., Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCalpha and TSC2-mTOR downregulation. Commun Biol. 2021 Mar 19;4(1):355
• All: 1 reference(s)