Gt(ROSA)26Sortm1(BEST1-cre/ERT2)Vold
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm1(BEST1-cre/ERT2)Vold |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Douglas Vollrath |
MGI ID: |
MGI:6711969 |
Synonyms: |
Rosa26BEST1-CreERT2 |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm1(BEST1-cre/ERT2)Vold page
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm1(BEST1-cre/ERT2)Vold expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Homolog in Mouse |
Note |
human |
BEST1 (7439) |
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Mutation details: The allele was created to have the human BEST1 promoter/enhancer regions directing the expression of a CreER(T2) fusion gene. The targeting vector contained, from 5' to 3', the human BEST1 promoter (nucleotides -585 to +38), followed by a CreER(T2) fusion gene, and an SV40 a polyA cassette. The plasmid was pronuclear injected into C57BL/6J(attPx3) zygotes along with phiC31 integrase mRNA. The resulting founder mice were bred with C57BL/6J for germline transmission.
(J:305495)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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BEST1
(human)
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Original: |
J:305495 Chen M, et al., An efficient inducible RPE-Selective cre transgenic mouse line. Exp Eye Res. 2021 Jan;202:108370 |
All: |
1 reference(s) |
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