Nebl^tm1.1Epu
Targeted Allele Detail

Summary

• Symbol: Nebl^tm1.1Epu
• Name: nebulette; targeted mutation 1.1, Enkhsaikhan Purevjav
• MGI ID: MGI:6711840
• Synonyms: Nebl^3ex-, Nebl^ex3-
• Gene: Nebl Location: Chr2:17348720-17736275 bp, - strand Genetic Position: Chr2, 12.43 cM, cytoband A2
• Alliance: Nebl^tm1.1Epu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:304786
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed neomycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 and the selection cassette. (J:304786)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nebl Mutation: 67 strains or lines available

References

• Original: J:304786 Vejandla RM, et al., Deficiency in Nebulin Repeats of Sarcomeric Nebulette is Detrimental for Cardiomyocyte Tolerance to Exercise and Biomechanical Stress. Am J Physiol Heart Circ Physiol. 2021 Apr 16
• All: 1 reference(s)