Ak2^em1.1Dze
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ak2^em1.1Dze
• Name: adenylate kinase 2; endonuclease-mediated mutation 1.1, Petras Dzeja
• MGI ID: MGI:6711698
• Gene: Ak2 Location: Chr4:128887017-128905322 bp, + strand Genetic Position: Chr4, 62.62 cM
• Alliance: Ak2^em1.1Dze page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology inserted a loxP site and FRT-flanked neomycin resistance gene upstream of exon 3 and a second loxP site downstream of exon 4. Flp-mediated recombination removed the selection cassette leaving exon 3-4 floxed. (J:305579)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ak2 Mutation: 24 strains or lines available

References

• Original: J:305579 Zhang S, et al., Adenylate kinase AK2 isoform integral in embryo and adult heart homeostasis. Biochem Biophys Res Commun. 2021 Mar 26;546:59-64
• All: 1 reference(s)