Foxp3tm11.2Ayr
Targeted Allele Detail
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Symbol: |
Foxp3tm11.2Ayr |
Name: |
forkhead box P3; targeted mutation 11.2, Alexander Y Rudensky |
MGI ID: |
MGI:6711582 |
Synonyms: |
CNS0delta, Foxp3deltaCNS0-GFP |
Gene: |
Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
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Alliance: |
Foxp3tm11.2Ayr page
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Germline Transmission: |
Earliest citation of germline transmission:
J:305560
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Modified regulatory region) |
Mutations: |
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Insertion, Intragenic deletion
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Foxp3tm11.2Ayr involves 2 genes/genome features (Ppp1r3f, Rr122)
View all
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Mutation details: A GFP reporter gene was inserted in-frame with the 5' end of the gene's coding sequence. The upstream conserved non-coding sequence 0 (CNS0 (Rr122), a STAT5-binding enhancer located at chrX:7436913-7437513 (GRCm39) within intron 1 of Ppp1r3f) was flanked upstream by a loxP site and downstream by an FRT site flanked neomycin resistance gene cassette and a second loxP site. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed CNS0.
(J:305560)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Foxp3 Mutation: |
61 strains or lines available
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Original: |
J:305560 Dikiy S, et al., A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance. Immunity. 2021 May 11;54(5):931-946.e11 |
All: |
2 reference(s) |
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