Fbxw11^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fbxw11^em1Cya
• Name: F-box and WD-40 domain protein 11; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6711456
• Synonyms: Fbxw11^em1Cgen, FBXW11^em1cyagen
• Gene: Fbxw11 Location: Chr11:32592724-32696816 bp, + strand Genetic Position: Chr11, 19.02 cM
• Alliance: Fbxw11^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting generated a conditional allele. (J:305766)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxw11 Mutation: 72 strains or lines available

References

• Original: J:305766 Sun J, et al., FBXW11 deletion alleviates Alzheimer's disease by reducing neuroinflammation and amyloid-beta plaque formation via repression of ASK1 signaling. Biochem Biophys Res Commun. 2021 Apr 9;548:104-111
• All: 1 reference(s)