Tet3^tm1.1Hko
Targeted Allele Detail

Summary

• Symbol: Tet3^tm1.1Hko
• Name: tet methylcytosine dioxygenase 3; targeted mutation 1.1, Haruhiko Koseki
• MGI ID: MGI:6711355
• Synonyms: Tet3^lox, Tet3^tm1.1Phjk
• Gene: Tet3 Location: Chr6:83339355-83434190 bp, - strand Genetic Position: Chr6, 35.94 cM
• Alliance: Tet3^tm1.1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236575
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 8. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 9. Flp-mediated recombination removed the selection cassette and left exons 8 and 9 floxed. (J:236575)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tet3 Mutation: 60 strains or lines available

References

• Original: J:236575 Amouroux R, et al., De novo DNA methylation drives 5hmC accumulation in mouse zygotes. Nat Cell Biol. 2016 Feb;18(2):225-33
• All: 4 reference(s)