Atp6v0a1^em3Hisa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Atp6v0a1^em3Hisa
• Name: ATPase, H+ transporting, lysosomal V0 subunit A1; endonuclease-mediated mutation 3, Hirotomo Saitsu
• MGI ID: MGI:6711347
• Synonyms: Atp6v0a1^KO
• Gene: Atp6v0a1 Location: Chr11:100900278-100954545 bp, + strand Genetic Position: Chr11, 64.04 cM
• Alliance: Atp6v0a1^em3Hisa page

Mutation origin

• Strain of Origin: ICR

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a 1 bp deletion in exon 13 resulting in a frameshift. (J:305201)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp6v0a1 Mutation: 42 strains or lines available

References

• Original: J:305201 Aoto K, et al., ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H(+)-ATPases is essential for brain development in humans and mice. Nat Commun. 2021 Apr 8;12(1):2107
• All: 1 reference(s)