Tc(HSA17)2Mdk
Targeted Allele Detail
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Symbol: |
Tc(HSA17)2Mdk |
Name: |
transchromosomal, human 17, line 2, Michael Koob; transchromosomal, human 17, line 2, Michael D Koob |
MGI ID: |
MGI:6705045 |
Synonyms: |
MAPT(H1.0)-GR |
Gene: |
Tc(HSA17)2Mdk Location: unknown Genetic Position: Chr11, Syntenic
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Alliance: |
Tc(HSA17)2Mdk page
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Germline Transmission: |
Earliest citation of germline transmission:
J:101977
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Parent Cell Line: |
PRX-B6N (ES Cell)
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Strain of Origin: |
C57BL/6NTac
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
Mutations: |
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Insertion, Intergenic deletion
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Tc(HSA17)2Mdk expresses
2 genes
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
MAPT (4137) |
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human |
SPPL2C (162540) |
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Mutation details: A 157 kb deletion on mouse chromosome 11 stretching from, but not including, Crhr1 to Kansl1 is replaced by a syntenic 190 kb region from human chromosome 17 (HSA17). The mouse Sppl2c (signal peptide peptidase 2C) and Mapt (microtubule-associated protein tau) genes are replaced by human SPPL2C and MAPT (H1 haplotype) genes. A loxN-flanked neomycin resistance cassette was removed by transient cre expression.
(J:101977)
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Original: |
J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017; |
All: |
1 reference(s) |
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