Prcp^tm1.1Sdno
Targeted Allele Detail

Summary

• Symbol: Prcp^tm1.1Sdno
• Name: prolylcarboxypeptidase (angiotensinase C); targeted mutation 1.1, Sabrina Diano
• MGI ID: MGI:6704957
• Synonyms: Prcp^fl
• Gene: Prcp Location: Chr7:92524461-92583789 bp, + strand Genetic Position: Chr7, 51.64 cM, cytoband E2
• Alliance: Prcp^tm1.1Sdno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260852
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (129 x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting construct obtained from EUCOMM is composed of FRT-splice acceptor-IRES-lacZ-polyA-loxP-neomycin cassette-poylA-FRT-loxP inserted upstream of exon 4. A third loxP site is inserted downstream of exon 4. Flp-mediated recombination removed the FRT-flanked lacZ and neo cassette leaving exon 4 floxed. (J:260852)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prcp Mutation: 29 strains or lines available

Notes

ES cell line = S1B6A

References

• Original: J:260852 Bruschetta G, et al., Prolyl carboxypeptidase in Agouti-related Peptide neurons modulates food intake and body weight. Mol Metab. 2018 Apr;10:28-38
• All: 2 reference(s)