Il27ra^tm1.1Bkim
Targeted Allele Detail

Summary

• Symbol: Il27ra^tm1.1Bkim
• Name: interleukin 27 receptor, alpha; targeted mutation 1.1, Byung Kim
• MGI ID: MGI:6704947
• Synonyms: Il27ra^fl, Il27ra^tm1.1Bkmin
• Gene: Il27ra Location: Chr8:84756923-84769218 bp, - strand Genetic Position: Chr8, 40.26 cM, cytoband C3
• Alliance: Il27ra^tm1.1Bkim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253624
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 7. An FRT-flanked neomycin resistance (neo) cassette, followed by a second loxP site, is inserted downstream of exon 8. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:253624)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il27ra Mutation: 31 strains or lines available

References

• Original: J:253624 Do J, et al., Treg-specific IL-27Ralpha deletion uncovers a key role for IL-27 in Treg function to control autoimmunity. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10190-10195
• All: 5 reference(s)