Ccdc8^tm1.2Yxi
Targeted Allele Detail

Summary

• Symbol: Ccdc8^tm1.2Yxi
• Name: coiled-coil domain containing 8; targeted mutation 1.2, Yue Xiong
• MGI ID: MGI:6695964
• Synonyms: Ccdc8^-, Ccdc8^KO
• Gene: Ccdc8 Location: Chr7:16727827-16731440 bp, + strand Genetic Position: Chr7, 9.15 cM
• Alliance: Ccdc8^tm1.2Yxi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303998
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The single coding exon was deleted via Cre-mediated recombination of flanking loxP sites. RNA in situ hybridization confirmed the absence of transcript expression in E12.5 homozygous mutant embryos. (J:303998)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccdc8 Mutation: 24 strains or lines available

References

• Original: J:303998 Wang P, et al., Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. J Clin Invest. 2019 Jul 25;129(10):4393-4407
• All: 1 reference(s)