Wdfy2^tm1.1Wgz
Targeted Allele Detail

Summary

• Symbol: Wdfy2^tm1.1Wgz
• Name: WD repeat and FYVE domain containing 2; targeted mutation 1.1, Wei-Guo Zhu
• MGI ID: MGI:6695933
• Gene: Wdfy2 Location: Chr14:63075127-63198958 bp, + strand Genetic Position: Chr14, 33.23 cM
• Alliance: Wdfy2^tm1.1Wgz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296933
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was flanked by loxP sites. The flanked fragment includes a sequence upstream of exon 3 (502 bp), 875 bp of the exon 3, and 497 bp of sequence downstream of exon 3. An FRT-flanked neomycin resistance cassette was inserted downstream of exon 3 before the second loxP site. Cre-mediated recombination removed exon 3 and the neomycin selection cassette. (J:296933)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdfy2 Mutation: 14 strains or lines available

References

• Original: J:296933 Zhang L, et al., WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls Endosomal Localization of the Insulin Receptor and IRS1/2. Diabetes. 2020 Sep;69(9):1887-1902
• All: 1 reference(s)