Irf3^tm1.1Evdr
Targeted Allele Detail

Summary

• Symbol: Irf3^tm1.1Evdr
• Name: interferon regulatory factor 3; targeted mutation 1.1, Evan Rosen
• MGI ID: MGI:6695702
• Synonyms: Irf3^flox
• Gene: Irf3 Location: Chr7:44647072-44652272 bp, + strand Genetic Position: Chr7, 29.07 cM, cytoband B2
• Alliance: Irf3^tm1.1Evdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:304593
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 3, and a second loxP site followed by an FRT-flanked PGK-neo cassette downstream of exon 6. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:304593)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irf3 Mutation: 35 strains or lines available

References

• Original: J:304593 Yan S, et al., IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis. J Clin Invest. 2021 Apr 1;131(7)
• All: 1 reference(s)