Tuba1a^tm1.1Dak
Targeted Allele Detail

Summary

• Symbol: Tuba1a^tm1.1Dak
• Name: tubulin, alpha 1A; targeted mutation 1.1, David A Keays
• MGI ID: MGI:6694888
• Synonyms: Tuba1a R402H
• Gene: Tuba1a Location: Chr15:98847728-98851382 bp, - strand Genetic Position: Chr15, 55.29 cM
• Alliance: Tuba1a^tm1.1Dak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297547
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Single point mutation
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neomycin resistance cassette with a 3' loxP site followed by a mutant exon 4 which codes for the amino acid substitution of arginine with histidine at position 402. Flp-mediated recombination removed the selection cassette. (J:297547)

Expression

In Mice Carrying this Mutation:

86 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tuba1a Mutation: 15 strains or lines available

References

• Original: J:297547 Leca I, et al., A proteomic survey of microtubule-associated proteins in a R402H TUBA1A mutant mouse. PLoS Genet. 2020 Nov;16(11):e1009104
• All: 1 reference(s)