Vps4b^em1.1Nju
Endonuclease-mediated Allele Detail

Summary

• Symbol: Vps4b^em1.1Nju
• Name: vacuolar protein sorting 4B; endonuclease-mediated mutation 1.1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:6694861
• Gene: Vps4b Location: Chr1:106698518-106724455 bp, - strand Genetic Position: Chr1, 50.1 cM, cytoband D
• Alliance: Vps4b^em1.1Nju page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 technology was used to flank exon 2 with loxP sites. Exon 2 was deleted via cre-mediated recombination. (J:304329)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vps4b Mutation: 20 strains or lines available

References

• Original: J:304329 Chen D, et al., VPS4B deficiency causes early embryonic lethality and induces signal transduction disorders of cell endocytosis. Genesis. 2021 Mar 7;:e23415
• All: 1 reference(s)