Tcf7^em1Dwl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tcf7^em1Dwl
• Name: transcription factor 7, T cell specific; endonuclease-mediated mutation 1, David Wiest
• MGI ID: MGI:6694841
• Synonyms: EPE^-
• Gene: Tcf7 Location: Chr11:52143198-52174158 bp, - strand Genetic Position: Chr11, 31.86 cM
• Alliance: Tcf7^em1Dwl page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing methods were used to delete a 500-bp region encompassing the regulatory E-protein-bound element (EPE) located in the first intron. (J:304284)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf7 Mutation: 29 strains or lines available

References

• Original: J:304284 Fahl SP, et al., The E protein-TCF1 axis controls gammadelta T cell development and effector fate. Cell Rep. 2021 Feb 2;34(5):108716
• All: 1 reference(s)