Zmpste24^tm1Lgf
Targeted Allele Detail

Summary

• Symbol: Zmpste24^tm1Lgf
• Name: zinc metallopeptidase, STE24; targeted mutation 1, Loren G Fong
• MGI ID: MGI:6694205
• Gene: Zmpste24 Location: Chr4:120916434-120955438 bp, - strand Genetic Position: Chr4, 56.8 cM
• Alliance: Zmpste24^tm1Lgf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:304050
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: BAC recombineering is used to create a targeting construct that contains a loxP site followed by a betageo cassette (a fusion of beta-galactosidase and neomycin phospotransferase II) inserted into intron 5. A second loxP site is inserted in intron 6. (J:304050)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zmpste24 Mutation: 33 strains or lines available

References

• Original: J:304050 Heizer PJ, et al., Deficiency in ZMPSTE24 and resulting farnesyl-prelamin A accumulation only modestly affect mouse adipose tissue stores. J Lipid Res. 2020 Mar;61(3):413-421
• All: 1 reference(s)