Pirb^em1Fgla
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pirb^em1Fgla
• Name: paired Ig-like receptor B; endonuclease-mediated mutation 1, Fadi G Lakkis
• MGI ID: MGI:6694115
• Gene: Pirb Location: Chr7:3715504-3723381 bp, - strand Genetic Position: Chr7, 2.14 cM
• Alliance: Pirb^em1Fgla page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Intron 8 and exon 15 were targeted with sgRNAs using CRISPR/Cas9 technology, resulting in the deletion of the genomic region containing exons 9 through the 5' part of 15. (J:290663)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pirb Mutation: 64 strains or lines available

References

• Original: J:290663 Dai H, et al., PIRs mediate innate myeloid cell memory to nonself MHC molecules. Science. 2020 Jun 5;368(6495):1122-1127
• All: 1 reference(s)