Tnfrsf11b^tm1Smoc
Targeted Allele Detail

Summary

• Symbol: Tnfrsf11b^tm1Smoc
• Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin); targeted mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6693624
• Synonyms: Opg-KO
• Gene: Tnfrsf11b Location: Chr15:54114014-54141700 bp, - strand Genetic Position: Chr15, 21.15 cM
• Alliance: Tnfrsf11b^tm1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303660
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Part of exon 2 was replaced with a neomycin selection cassette. (J:303660)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfrsf11b Mutation: 33 strains or lines available

References

• Original: J:303660 Xu Y, et al., High-bone-turnover Osteoporosis and Aortic calcification in Opg knockout mice. Progress in Biochemistry and Biophysics. 2007;34(3):260-266
• All: 7 reference(s)