Adrb1^tm1.1Jmz
Targeted Allele Detail

Summary

• Symbol: Adrb1^tm1.1Jmz
• Name: adrenergic receptor, beta 1; targeted mutation 1.1, Jeffrey M Zigman
• MGI ID: MGI:6693436
• Synonyms: beta1AR^fl
• Gene: Adrb1 Location: Chr19:56710549-56713582 bp, + strand Genetic Position: Chr19, 51.96 cM
• Alliance: Adrb1^tm1.1Jmz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237298
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The single coding exon of the gene was flanked by loxP sites. An frt-flanked neomycin selection cassette was removed via FLP1 mediated recombination. (J:237298)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adrb1 Mutation: 20 strains or lines available

References

• Original: J:237298 Mani BK, et al., beta1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals. J Clin Invest. 2016 Sep 01;126(9):3467-78
• All: 4 reference(s)