Adam22^em2Mafu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adam22^em2Mafu
• Name: a disintegrin and metallopeptidase domain 22; endonuclease-mediated mutation 2, Masaki Fukata
• MGI ID: MGI:6693430
• Synonyms: Adam22^deltaC5
• Gene: Adam22 Location: Chr5:8122352-8418160 bp, - strand Genetic Position: Chr5, 3.39 cM
• Alliance: Adam22^em2Mafu page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a deletion of the sequences encoding the C-terminal five residues of the encoded protein. (J:300752)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam22 Mutation: 71 strains or lines available

References

• Original: J:300752 Fukata Y, et al., LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2022580118
• All: 1 reference(s)