Axl^em1Ebt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Axl^em1Ebt
• Name: AXL receptor tyrosine kinase; endonuclease-mediated mutation 1, Edward B Thorp
• MGI ID: MGI:6690906
• Synonyms: Axl^CR, Axl^em1Irb
• Gene: Axl Location: Chr7:25456698-25488130 bp, - strand Genetic Position: Chr7, 14.02 cM, cytoband A3-B1
• Alliance: Axl^em1Ebt page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a deletion of CCCCCACCTCGCGCCTTC between exons 10 and 11. This deleted a 6amino acid region of the encoded protein within a 14amino acid stalk region proximal to the transmembrane domain. The resulting protein is cleavage-resistant. (J:303591)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Axl Mutation: 58 strains or lines available

References

• Original: J:303591 DeBerge M, et al., Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction. J Clin Invest. 2021 Mar 15;131(6)
• All: 1 reference(s)