Mospd2^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: Mospd2^tm1.2Geno
• Name: motile sperm domain containing 2; targeted mutation 1.2, Genoway
• MGI ID: MGI:6690853
• Synonyms: MOSPD2 KO
• Gene: Mospd2 Location: ChrX:163719165-163763371 bp, - strand Genetic Position: ChrX, 76.75 cM, cytoband F5
• Alliance: Mospd2^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301755
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site and FRT-flanked neomycin selection cassette were inserted upstream of exon 4 and a loxP site was inserted downstream of exon 5 via homologous recombination. The FRT-flanked neomycin selection cassette was deleted via FLP1-mediated recombination and exons 4-5 were deleted via Cre-mediated recombination in the germline. Western blot analysis confirmed the absence of protein expression in the spleen, bone marrow, and thymus of homozygous mutant mice. (J:301755)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mospd2 Mutation: 13 strains or lines available

References

• Original: J:301755 Yacov N, et al., MOSPD2 is a therapeutic target for the treatment of CNS inflammation. Clin Exp Immunol. 2020 Aug;201(2):105-120
• All: 1 reference(s)