Phf6^em1Utr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Phf6^em1Utr
• Name: PHD finger protein 6; endonuclease-mediated mutation 1, University of Tsukuba Laboratory Animal Resource Center
• MGI ID: MGI:6690449
• Synonyms: Phf6^fl
• Gene: Phf6 Location: ChrX:52001143-52045820 bp, + strand Genetic Position: ChrX, 29.28 cM, cytoband A4
• Alliance: Phf6^em1Utr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into introns 3 and 5 using sgRNAs and an ssODN plasmid template with CRISPR/Cas9 technology. (J:276437)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Phf6 Mutation: 12 strains or lines available

References

• Original: J:276437 Miyagi S, et al., The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells. Blood. 2019 Jun 6;133(23):2495-2506
• All: 1 reference(s)