Ldlr^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ldlr^em1Gpt
• Name: low density lipoprotein receptor; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:6682152
• Synonyms: Ldlr^em1Cd82
• Gene: Ldlr Location: Chr9:21634872-21661215 bp, + strand Genetic Position: Chr9, 7.87 cM
• Alliance: Ldlr^em1Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 4 deleted 82 nucleotides from the coding sequence. (J:300339)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ldlr Mutation: 78 strains or lines available

References

• Original: J:300339 Xie Y, et al., Aberrant oligodendroglial LDL receptor orchestrates demyelination in chronic cerebral ischemia. J Clin Invest. 2021 Jan 4;131(1)
• All: 8 reference(s)