Zfyve27^tm2Kei
Targeted Allele Detail

Summary

• Symbol: Zfyve27^tm2Kei
• Name: zinc finger, FYVE domain containing 27; targeted mutation 2, Keiichi I Nakayama
• MGI ID: MGI:6515782
• Synonyms: Protrudin^-
• Gene: Zfyve27 Location: Chr19:42159006-42183032 bp, + strand Genetic Position: Chr19, 35.87 cM
• Alliance: Zfyve27^tm2Kei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296912
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neomycin resistance gene cassette. Immunohistochemistry confirmed the lack of peptide expression from this allele in brain. (J:296912)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfyve27 Mutation: 25 strains or lines available

References

• Original: J:296912 Shirane M, et al., Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation. Nat Commun. 2020 Sep 11;11(1):4576
• All: 1 reference(s)