Usp20^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Usp20^em1Cya
• Name: ubiquitin specific peptidase 20; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6515595
• Synonyms: Usp20^em1Cgen, Usp20^KI, USP20(S132A/S134A)
• Gene: Usp20 Location: Chr2:30872291-30912667 bp, + strand Genetic Position: Chr2, 21.77 cM, cytoband B
• Alliance: Usp20^em1Cya page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• CRISPR-targeting introduced the amino acid substitutions S132A (TCT to GCT) and S134A (TCT to GCT). (J:299971)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp20 Mutation: 49 strains or lines available

References

• Original: J:299971 Lu XY, et al., Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis. Nature. 2020 Dec;588(7838):479-484
• All: 1 reference(s)