Ucp1^em1Beij
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ucp1^em1Beij
• Name: uncoupling protein 1 (mitochondrial, proton carrier); endonuclease-mediated mutation 1, Chinese Academy of Sciences
• MGI ID: MGI:6515569
• Synonyms: Ucp1-2A-GFP
• Gene: Ucp1 Location: Chr8:84016981-84025081 bp, + strand Genetic Position: Chr8, 39.65 cM
• Alliance: Ucp1^em1Beij page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Reporter)
• Mutation: Insertion
• Mutation details: CRISPR-targeting inserted a 2A peptide (GSGATNFSLLKQAGDVEENPGP) and GFP reporter gene at the end of exon 6 just before the stop codon. (J:278923)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ucp1 Mutation: 51 strains or lines available

References

• Original: J:278923 Qiu Y, et al., Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue. EBioMedicine. 2018 Nov;37:344-355
• All: 3 reference(s)