Il11^em2Cook
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il11^em2Cook
• Name: interleukin 11; endonuclease-mediated mutation 2, Stuart A Cook
• MGI ID: MGI:6514818
• Gene: Il11 Location: Chr7:4775372-4785858 bp, - strand Genetic Position: Chr7, 2.76 cM
• Alliance: Il11^em2Cook page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 genome editing is used to delete exons 2-4. This deletion is predicted to cause a shift in the reading frame from the splicing of coding sequences present within exons 1 and 5, resulting in the generation of a mutant peptide (62 amino acid in length) that does not align to that of known proteins. This effectively results in the inactivation of the gene. (J:307608)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il11 Mutation: 21 strains or lines available

References

• Original: J:307608 Ng B, et al., Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis. Sci Rep. 2021 Jul 8;11(1):14088
• All: 2 reference(s)