Trim7^em3Raj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trim7^em3Raj
• Name: tripartite motif-containing 7; endonuclease-mediated mutation 3, Ricardo Rajsbaum
• MGI ID: MGI:6514756
• Synonyms: 3240B
• Gene: Trim7 Location: Chr11:48716965-48742019 bp, + strand Genetic Position: Chr11, 28.8 cM
• Alliance: Trim7^em3Raj page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutations: Intragenic deletion, Single point mutation
• Mutation details: CRISPR/cas9 mediated recombination created a 2 nt GG deletion (48837539-48837540) and a G-C substitution at position 48837541 in exon 1 and a 3 nt CAC deletion (48849905-48849907) in exon 7. A truncated protein is expressed by this allele. (J:296988)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim7 Mutation: 42 strains or lines available

References

• Original: J:296988 Giraldo MI, et al., Envelope protein ubiquitination drives entry and pathogenesis of Zika virus. Nature. 2020 Sep;585(7825):414-419
• All: 1 reference(s)