Tardbpem2.1(TARDBP)H
Endonuclease-mediated Allele Detail
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Symbol: |
Tardbpem2.1(TARDBP)H |
Name: |
TAR DNA binding protein; endonuclease-mediated mutation 2.1, Harwell |
MGI ID: |
MGI:6513996 |
Synonyms: |
TARDBP (A02) EM Flp excised |
Gene: |
Tardbp Location: Chr4:148696839-148711476 bp, - strand Genetic Position: Chr4, 78.77 cM
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Alliance: |
Tardbpem2.1(TARDBP)H page
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Allele Type: |
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Endonuclease-mediated (Humanized sequence, Inserted expressed sequence, Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Tardbpem2.1(TARDBP)H expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
TARDBP (23435) |
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Mutation details: A BAC targeting construct harbouring the mouse Tardpb locus (BAC B6Ng01-103M13) was engineered to replace the gene from the ATG start site to the TAG stop codon with the orthologous human TARDBP genomic sequence derived from a BAC with the human TARDPB locus (BAC RP11-829B14), and an FRT-flanked PGK/gb2/Neo cassette was inserted into intron 3 of the human gene. Flp-mediated recombination removed the selection cassette.
(J:342505)
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Original: |
J:342505 Devoy A, et al., Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models. iScience. 2021 Dec 17;24(12):103463 |
All: |
2 reference(s) |
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