Cd274^tm3.1Shr
Targeted Allele Detail

Summary

• Symbol: Cd274^tm3.1Shr
• Name: CD274 antigen; targeted mutation 3.1, Arlene H Sharpe
• MGI ID: MGI:6512855
• Synonyms: PD-L1 F
• Gene: Cd274 Location: Chr19:29344855-29365495 bp, + strand Genetic Position: Chr19, 23.88 cM, cytoband C2
• Alliance: Cd274^tm3.1Shr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261659
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert loxP sites flanking exons 2-3. An FRT-flanked neomycin resistance (neo) cassette is inserted inserted 148 bp 5' of exon 2, within the intron between exons 1 and 2. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:261659)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd274 Mutation: 71 strains or lines available

References

• Original: J:261659 Sage PT, et al., Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function. J Immunol. 2018 Apr 15;200(8):2592-2602
• All: 4 reference(s)