Hprt1^tm1(GRN)Blrl
Targeted Allele Detail

Summary

• Symbol: Hprt1^tm1(GRN)Blrl
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Blair R Leavitt
• MGI ID: MGI:6512847
• Synonyms: GRN^Tg
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^tm1(GRN)Blrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303265
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^tm1(GRN)Blrl expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GRN (2896)

  Grn	(MGI:95832)

• Mutation details: The targeting construct is created using bacterial artificial chromosome RP11-1145H1, carrying a 170 kb insert from human chromosome 17. The BAC includes the entire GRN coding sequence (8 kb) plus approximately 8 kb of upstream sequence. The 35 kb construct including Hprt homologous recombination targeting arms was inserted into the Hprt locus. (J:303265)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1280 strains or lines available

References

• Original: J:303265 Petkau TL, et al., Human progranulin-expressing mice as a novel tool for the development of progranulin-modulating therapeutics. Neurobiol Dis. 2021 Feb 24;153:105314
• All: 2 reference(s)