Gcg^em1(cre)Utr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gcg^em1(cre)Utr
• Name: glucagon; endonuclease-mediated mutation 1, University of Tsukuba Laboratory Animal Resource Center
• MGI ID: MGI:6512088
• Synonyms: Gcg-Cre
• Gene: Gcg Location: Chr2:62304874-62313994 bp, - strand Genetic Position: Chr2, 35.85 cM
• Alliance: Gcg^em1(cre)Utr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Gcg^em1(cre)Utr expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gcg (MGI:95674)

• Mutation details: A self-cleaving 2A-NLS-Cre gene sequence was inserted just before the stop codon via the CRISPR-Cas9 genome editing technology. (J:302484)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gcg (mouse) Summary of all recombinase alleles driven by Gcg. Comparative matrix view of recombinase activities Alliance mouse Gcg gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gcg Mutation: 32 strains or lines available

References

• Original: J:302484 Chang YH, et al., Uncovering the role of MAFB in glucagon production and secretion in pancreatic alpha-cells using a new alpha-cell-specific Mafb conditional knockout mouse model. Exp Anim. 2020 Apr 24;69(2):178-188
• All: 1 reference(s)