Tlr4^tm2Jke
Targeted Allele Detail

Summary

• Symbol: Tlr4^tm2Jke
• Name: toll-like receptor 4; targeted mutation 2, Joel Elmquist
• MGI ID: MGI:6512038
• Synonyms: Tlr4^LoxTB
• Gene: Tlr4 Location: Chr4:66745788-66765338 bp, + strand Genetic Position: Chr4, 34.66 cM
• Alliance: Tlr4^tm2Jke page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303176
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting construct is designed to have a loxP-flanked transcriptional blocking (TB) cassette inserted into intron 2. (J:303176)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr4 Mutation: 96 strains or lines available

References

• Original: J:303176 Jia L, et al., TLR4 Signaling Selectively and Directly Promotes CGRP Release from Vagal Afferents in the Mouse. eNeuro. 2021 Jan-Feb;8(1):ENEURO.0254-20.2020
• All: 6 reference(s)